Asthma Diagnosis and Management

This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes.

Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease "phenotype" and "endotype," which allowed precision medicine therapies, including new asthma biologics.
Contents
1 Noninvasive Biomarkers of Asthma
2 Epidemiological Aspects of Rhinitis and Asthma: Comorbidity or United Airway Disease
3 Meaning of Endotype-Phenotype in Pédiatrie Respiratory Pathology
4 Functional Lung Examination in Diagnostics of Asthma and Its Phenotypes
5 Asthma in the Disadvantaged: A Phenotype in Need of a Personalized, Multidisciplinary Approach to Therapy
6 Phosphodiesterase 3 and 4 Inhibition: Facing a Bright Future in Asthma Control
7 Subcellular Organelles in Immune Responses of Severe Asthma: The Rôles of Mitochondria and Endoplasmic Reticulum
8 Severe Asthma: Updated Therapy Approach Based on Phenotype and Biomarker
9 Monoclonal Antibodies for Asthma Management
10 The Asthma Obese Phenotype
11 Use of Omalizumab as Treatment in Patients with Moderate and Severe Non-Atopic Asthma and Associated with Asthma-COPD Overlap Syndrome (ACOS)
12 Cough Variant Asthma as a Phenotype of Classic Asthma

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