GERD:A New Understanding of Pathology, Pathophysiology, and Treatment 1st Edition

GERD: A New Understanding of Pathology, Pathophysiology, and Treatment 1st Edition
Authors: Parakrama Chandrasoma
eBook ISBN: 9780128098561
Hardcover ISBN: 9780128098554
Imprint: Academic Press
Copyright 2018 Elsevier Inc. All rights reserved.
Page Count: 652
DOI: https://doi.org/10.1016/C2015-0-06626-6
PDF 71Mb


Description

GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible.

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