Pancreatic Islet Isolation: From the Mouse to the Clinic

Pancreatic Islet Isolation: From the Mouse to the Clinic by Miriam Ramírez-Domínguez
ISBN: 3319398229 | 2016 | 136 pages | PDF

Pancreatic islets make up the endocrine pancreas and they contain the only source of insulin in the body, beta cells. Hence, access to high quality preparations of pancreatic islets is fundamental for in vitro studies and to test pre-clinical applications in animal models in vivo. Access to healthy human islets is also crucial to improve transplantation procedures for diabetes. Given the susceptibility of pancreatic islets to the enzymatic digestion and mechanical stress required to obtain them, the isolation of islets is often considered as the delicate “work of a craftsman”.

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